{"id":17926,"date":"2023-10-06T12:29:45","date_gmt":"2023-10-06T04:29:45","guid":{"rendered":"https:\/\/virtual.math.ntnu.edu.tw\/?p=17926"},"modified":"2023-10-06T12:29:45","modified_gmt":"2023-10-06T04:29:45","slug":"lecture_20231018","status":"publish","type":"post","link":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/2023\/10\/06\/lecture_20231018\/","title":{"rendered":"<span style=\"color:#3566BD\">[\u5c08\u984c\u6f14\u8b1b] <\/span>\u301010\u670818\u65e5\u3011Stephen Payne \/ Multi-scale, multi-compartment modelling of the human brain"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"17926\" class=\"elementor elementor-17926\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-19a5332c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"19a5332c\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-68eb95a1\" data-id=\"68eb95a1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4d878518 elementor-widget elementor-widget-heading\" data-id=\"4d878518\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Multi-scale, multi-compartment modelling of the human brain<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51461cf0 elementor-widget elementor-widget-spacer\" data-id=\"51461cf0\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ccaf3ea elementor-widget elementor-widget-text-editor\" data-id=\"4ccaf3ea\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p><span style=\"color: #000080; font-family: \u5fae\u8edf\u6b63\u9ed1\u9ad4; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: bold;\">\u6642\u3000\u9593\uff1a2023-10-18 14:00 (\u661f\u671f\u4e09) \/ \u5730\u3000\u9ede\uff1aS101 \/ \u8336\u3000\u6703\uff1aS205 (13:30)<\/span><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4940900d elementor-widget elementor-widget-image\" data-id=\"4940900d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"300\" height=\"300\" src=\"https:\/\/virtual.math.ntnu.edu.tw\/wp-content\/uploads\/2023\/10\/1121018Payne-1.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/virtual.math.ntnu.edu.tw\/wp-content\/uploads\/2023\/10\/1121018Payne-1.jpg 300w, https:\/\/virtual.math.ntnu.edu.tw\/wp-content\/uploads\/2023\/10\/1121018Payne-1-150x150.jpg 150w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26032a62 elementor-widget elementor-widget-text-editor\" data-id=\"26032a62\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<div style=\"list-style: none; font-family: \u5fae\u8edf\u6b63\u9ed1\u9ad4; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; margin-top: 10px; font-size: 22px; line-height: 26px; text-align: center; color: #cc6633; font-weight: bold;\">Stephen Payne<br \/>\u6f58\u65af\u6587 \u6559\u6388<\/div><div style=\"list-style: none; font-family: \u5fae\u8edf\u6b63\u9ed1\u9ad4; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; margin-top: 10px; font-size: 18px; line-height: 22px; text-align: center; color: #cc9966; font-weight: bold;\">(National Taiwan University)<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5c79e75 elementor-widget elementor-widget-spacer\" data-id=\"5c79e75\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5fd7cb59 elementor-widget elementor-widget-text-editor\" data-id=\"5fd7cb59\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>The increasing rates of cerebrovascular diseases, such as stroke and dementia, mean that understanding cerebral blood flow and its control in both healthy and diseased states has become an important clinical problem. However this is made challenging by the spatial and temporal limitations of human brain imaging and the number of blood vessels involved in a what is a highly complex dynamic regulating system over many length scales. In this talk I will discuss the work that we have done to construct models of cerebral blood flow that cover the many length scales involved, running from a few micrometres to a few millimetres. I will show how we have developed such models from the bottom up, through highly detailed modelling of the microcirculation and the application of homogenisation and optimisation methods, in order to generate a full-brain model of blood flow and oxygen transport. I will then talk about how this can be applied (and validated) in pathological conditions, in particular the treatment of acute ischaemic stroke. I will conclude by discussing how we next plan to use multiple time scales in the context of chronic diseases such as dementia and to quantify the effects of interventions such as sleep and exercise on disease progression.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76d951d3 elementor-widget elementor-widget-image\" data-id=\"76d951d3\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"1240\" height=\"758\" src=\"https:\/\/virtual.math.ntnu.edu.tw\/wp-content\/uploads\/2020\/08\/\u6f14\u8b1b\u6a19\u5c3e.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/virtual.math.ntnu.edu.tw\/wp-content\/uploads\/2020\/08\/\u6f14\u8b1b\u6a19\u5c3e.jpg 1240w, https:\/\/virtual.math.ntnu.edu.tw\/wp-content\/uploads\/2020\/08\/\u6f14\u8b1b\u6a19\u5c3e-300x183.jpg 300w, https:\/\/virtual.math.ntnu.edu.tw\/wp-content\/uploads\/2020\/08\/\u6f14\u8b1b\u6a19\u5c3e-768x469.jpg 768w, https:\/\/virtual.math.ntnu.edu.tw\/wp-content\/uploads\/2020\/08\/\u6f14\u8b1b\u6a19\u5c3e-1024x626.jpg 1024w\" sizes=\"(max-width: 1240px) 100vw, 1240px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<p class=\"wpf_wrapper\"><a class=\"print_link\" href=\"\" target=\"_blank\">\u53cb\u5584\u5217\u5370<\/a><\/p><!-- .wpf_wrapper -->","protected":false},"excerpt":{"rendered":"<p>Multi-scale, multi-compartment modelling of the human b [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1,124],"tags":[],"_links":{"self":[{"href":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/wp-json\/wp\/v2\/posts\/17926"}],"collection":[{"href":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/wp-json\/wp\/v2\/comments?post=17926"}],"version-history":[{"count":4,"href":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/wp-json\/wp\/v2\/posts\/17926\/revisions"}],"predecessor-version":[{"id":17931,"href":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/wp-json\/wp\/v2\/posts\/17926\/revisions\/17931"}],"wp:attachment":[{"href":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/wp-json\/wp\/v2\/media?parent=17926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/wp-json\/wp\/v2\/categories?post=17926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/virtual.math.ntnu.edu.tw\/index.php\/wp-json\/wp\/v2\/tags?post=17926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}